In Canada, an estimated 5400 deaths attributable to AMR occurred in 2018.1 By 2050, 40% of infections will be resistant to first-line antimicrobials.1 The pan-Canadian action plan on AMR has outlined ...

Background: Standard pharmacotherapy for patients with heart failure with reduced ejection fraction (HFrEF) comprises “quadruple therapy” with a renin–angiotensin system inhibitor, a β-blocker, a ...

Access to health care: Emergency department use before cancer diagnosis in Ontario, Canada: a population-based study ...

See related research at KEY POINTS In this issue of CMAJ , Van and colleagues present a cost–utility analysis of several different strategies for introduction of guideline-directed medical therapy ...

The syndrome of thrombocytopenia, anasarca, reticulin fibrosis, renal dysfunction, organomegaly (TAFRO) is a rare subtype of idiopathic multicentric Castleman disease. This syndrome should be ...

Solutions are needed in Canada to meet the health care needs of the growing number of adults with complex genetic neurodevelopmental conditions who have aged out of pediatric systems into adult ...

Anal cancer is caused mainly by human papillomavirus (HPV), most commonly HPV-16. It occurs in 1–2 per 100 000 people in the general population, increases with older age, and is rare in those younger ...

KEY POINTS A 35-year-old woman was admitted to a community hospital for sepsis caused by Streptococcus pyogenes bacteremia, ...