The San Francisco 49ers and Los Angeles Rams have aspirations of winning the NFC West and making another Super Bowl run, but both are dealing with significant losses on offense entering Week 3 when they go head-to-head.

Then again, you may end up watching a lot of the Jaguars vs Bills game as most people will have Cincinnati, who's sitting at 0-2 in their survivor pools as they host the Redskins with the later kickoff at 8:20 Eastern. The Bengals can't drop to 0-3, but do we want to pay for the juiciest Week 3 moneyline?