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WEBSep 18, 2024 · One sickle cell disease (SCD) patient may need as many as 50 units of blood and up to 25 units of platelets for the new cell-based gene therapies such as Casgevy and Lyfgenia to be successfully administered, according to the American Red Cross. As a part of…. September 16, 2024 Columns by Dunstan Nicol-Wilson.
Some ways to prevent infections in life with sickle cell disease
WEB2 days ago · Maintaining a balanced diet rich in fruits, vegetables, minerals, and antioxidants. Staying hydrated. Caring for wounds properly, which is essential since leg ulcers are common complications of sickle cell disease. Avoiding close contact with sick individuals, or using masks, gloves, and other protective gear when contact is unavoidable.
Vaso-Occlusive Crisis - Sickle Cell Disease News
WEBJan 4, 2022 · A vaso-occlusive crisis, or VOC, occurs when sickled red blood cells block blood flow to the point that tissues become deprived of oxygen. This in turn sets in motion an inflammatory response as the body tries to rectify the problem. The result is substantial pain, which can affect any part of the body, but most commonly occurs in the back ...
Risk of blood clots more likely with sickle cell trait, but still low
WEBSep 19, 2024 · Still, the researchers said, the risk of these blood clots was low, occurring in just over 2% of people carrying SCT. The study, “ Ancestry-Independent Risk of Venous Thromboembolism in Individuals with Sickle Cell Trait vs. Factor V Leiden,” was published in Blood Advances. “I hope this study informs health professionals, particularly hematologists, that when thinking about risks ...
Gene Therapy – Sickle Cell Disease News
WEBFour trials (NCT02186418, NCT03282656, NCT02247843, NCT02140554) are testing the efficacy and safety of gene therapy to replace the mutated HBB gene with a healthy HBB gene.These Phase 2 trials are recruiting both children and adults in the United States and Jamaica. Three trials (NCT02193191, NCT02989701, NCT03226691) are investigating the use of Mozobil (plerixafor) in patients with sickle ...
Here’s What Triggers a Sickle Cell Crisis for Me
WEBOct 9, 2020 · I began this column with a caveat about how sickle cell can affect each patient differently, because it is important to note that a trigger for me isn’t necessarily a trigger for other sickle cell patients. As I mentioned, cold weather is a big trigger for me, but for others, hot weather is a trigger. Let’s remember that each patient is an ...
NIH grant to determine if sickle cell gene editing harmful or...
WEBJul 25, 2023 · The four-year grant from the National Institutes of Health (NIH) was awarded to Gang Bao, PhD, a bioengineer at Rice. Following up on a discovery, led by Bao, that the gene editing technology called CRISPR/Cas9 leads to larger than expected modifications of genetic material, he and his team want to better understand the biological consequences of these changes, some of which might be helpful ...
Sigma Gamma Rho Sorority pledges $2M to hospital treating …
WEB2 days ago · by Andrea Lobo, PhD September 24, 2024. Sigma Gamma Rho Sorority, a national collegiate women’s organization, has committed to raising $2 million by 2028 to support St. Jude Children’s Research Hospital in its efforts to treat children with sickle cell disease (SCD), cancer, and other serious conditions at no cost to their families. The ...
Stem cell transplant for sickle cell disease
WEBAug 21, 2024 · A stem cell transplant — also known as a bone marrow transplant, and more formally referred to as hematopoietic stem cell transplantation (HSCT) — is an invasive procedure that can be used to enable people with sickle cell disease (SCD) to produce healthy red blood cells. The bone marrow is home …
Sickle Cell Patients at Higher Risk of Death From Kidney Disease
WEBNov 1, 2022 · During that time, 2,194,079 people developed ESKD, 2,018 (0.09%) of whom had an SCD diagnosis. SCD patients were diagnosed with kidney failure at a significantly younger age, by about 10 years, than people without SCD.